Distal Intestinal Obstruction Syndrome ( DIOS ) AND Cystic Fibrosis

Complete or incomplete blockage by mucilaginous soiled material within the terminal small intestine and proximal colon – distal intestinal blockage syndrome (DIOS) – is a common complication in Cystic fibrosis. DIOS is principally seen in patients with pancreatic insufficiency.

Meconium intestinal obstruction at birth, distal intestinal blockage syndrome (DIOS), and constipation are an interconnected cluster of intestinal blockage syndromes with a variable severity of obstruction that happens in Cystic fibrosis patients. DIOS and constipation are oftentimes seen in Cystic fibrosis patients, particularly later in life; genetic, dietary, and alternative associations are explored. The pathological process of DIOS is part thanks to loss of CFTR perform within the viscus wherever it regulates chloride secretion from the crypts, carbonate secretion from Brunner’s glands and metallic element transport. ileus has been reported as a significant explanation for mortality in CF mice with severe CFTR mutations.  Additionally to defective chloride secretion, CFTR regulates EnaC, NHE3 and ion exchangers resulting in excess absorption and reduced secretion of fluid, that contributes to viscus obstruction. 

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