Gastrointestinal and Cystic fibrosis

We have utilized in situ union to localize expression of the CF transmembrane electrical phenomenon regulator (CFTR) factor within the human gastrointestinal tract and associated organs. The abdomen exhibits a coffee level of CFTR expression throughout stomach membrane. within the gut, expression is comparatively high within the small intestine, with a decreasing gradient of expression on the sepulture to tip axis. The cells of the Brunner's glands specific high levels of CFTR informational RNA. Additionally, there's a little population of extremely positive cells scattered along the epithelium within the small intestine (duodenum and jejunum), however not within the ileum. These cells don't represent endocrine cells, as determined by lack of colocalization with associate degree endocrine-specific marker. The distribution of CFTR informational RNA within the colon is comparable to the tiny gut (small intestine), with highest level of expression within the epithelial cells at the bottom of the crypts. within the pancreatic gland, CFTR is expressed at high levels within the tiny, intercalated ducts and at lower levels within the interlobular ducts. CFTR transcripts are expressed at uniformly high levels within the epithelium of the gallbladder. Throughout the GI tract, CFTR expression is raised in mucosal epithelial cells that are close to body fluid nodules.

 

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